Compound Detail
CHEMBL5422526
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Basic Information
| ChEMBL ID | CHEMBL5422526 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VCBAAPOFZFWPPT-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
393.4
MW (Da)
2.35
ALogP
8
HBA
3
HBD
131.8
PSA (Ų)
0.46
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.19 | 7.19 | 64.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 64.0 | nM | 7.19 | Inhibition of human recombinant VEGFR-2 in the presence of ATP | 38389872 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38389872 | 10.1039/d3md00506b | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine