Compound Detail
CHEMBL5423317
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Basic Information
| ChEMBL ID | CHEMBL5423317 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LKHYBZAPEXNCLR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
366.4
MW (Da)
1.17
ALogP
8
HBA
2
HBD
114.4
PSA (Ų)
0.84
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha CHEMBL1075102 | IC50 | 7.89 | 7.89 | 13.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha | IC50 | = | 13.0 | nM | 7.89 | Inhibition of N-terminal 6His-tagged PI3KC2alpha (299 to 1388 residues) (unknown... | 37819647 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37819647 | 10.1021/acs.jmedchem.3c01319 | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha | 1 |
Data from ChEMBL 36 via Core Engine