Compound Detail
CHEMBL5427321
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Basic Information
| ChEMBL ID | CHEMBL5427321 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QFBPGHGSKMFUDY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
347.4
MW (Da)
2.85
ALogP
8
HBA
2
HBD
103.8
PSA (Ų)
0.55
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| eIF-2-alpha kinase GCN2 CHEMBL5358 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| eIF-2-alpha kinase GCN2 | IC50 | = | 4.0 | nM | 8.4 | Inhibition of human recombinant GCN2 using eIF2alpha as substrate | 36724635 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36724635 | 10.1016/j.ejmech.2023.115101 | eIF-2-alpha kinase GCN2 | 1 |
Data from ChEMBL 36 via Core Engine