Compound Detail
CHEMBL5427975
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Basic Information
| ChEMBL ID | CHEMBL5427975 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UPQKJUKBBWRZJU-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
428.9
MW (Da)
2.51
ALogP
4
HBA
4
HBD
116.4
PSA (Ų)
0.55
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.0
IC50 1 meas. best 5.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Eukaryotic peptide chain release factor GTP-binding subunit ERF3A CHEMBL4523593 | EC50 | 7.0 | 7.0 | 100.0 | 1 |
| Protein cereblon/DNA damage-binding protein 1 CHEMBL4630734 | IC50 | 5.47 | 5.47 | 3400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Eukaryotic peptide chain release factor GTP-binding subunit ERF3A | EC50 | = | 100.0 | nM | 7.0 | Induction of ePL tagged GSPT1 degradation in human DF15 cells incubated for 20 h... | 37991844 |
| Protein cereblon/DNA damage-binding protein 1 | IC50 | = | 3400.0 | nM | 5.47 | Displacement of Cy5-labeled tracer CC0782985 from 6His-tagged CRBN (1 to 442 res... | 37991844 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37991844 | 10.1021/acs.jmedchem.3c01848 | Zinc finger protein Aiolos | 2 |
| 37991844 | 10.1021/acs.jmedchem.3c01848 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A | 2 |
| 37991844 | 10.1021/acs.jmedchem.3c01848 | Protein cereblon/DNA damage-binding protein 1 | 1 |
Data from ChEMBL 36 via Core Engine