Compound Detail
CHEMBL5428346
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5428346 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XVQIMXCPWMKAOY-WJDWOHSUSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
306.3
MW (Da)
3.19
ALogP
3
HBA
1
HBD
70.0
PSA (Ų)
0.89
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone acetyltransferase KAT8 CHEMBL1932912 | IC50 | 4.54 | 4.54 | 29200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone acetyltransferase KAT8 | IC50 | = | 29200.0 | nM | 4.54 | Inhibition of N-terminal 6His tagged KAT8 (173 to 458 residues) (unknown origin)... | 37155735 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37155735 | 10.1021/acs.jmedchem.2c01937 | Histone acetyltransferase KAT8 | 1 |
| 37155735 | 10.1021/acs.jmedchem.2c01937 | Histone acetyltransferase p300 | 1 |
| 37155735 | 10.1021/acs.jmedchem.2c01937 | Histone acetyltransferase KAT2B | 1 |
Data from ChEMBL 36 via Core Engine