Compound Detail
CHEMBL5428637
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Basic Information
| ChEMBL ID | CHEMBL5428637 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FSQMUFXJBGUUNZ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
452.5
MW (Da)
2.66
ALogP
7
HBA
4
HBD
116.4
PSA (Ų)
0.51
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 7.42 | 7.42 | 38.2 | 1 |
| Serine/threonine-protein kinase Chk1 CHEMBL4630 | IC50 | 6.87 | 6.87 | 134.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 38.25 | nM | 7.42 | Inhibition of FLT3 D835Y mutant (unknown origin) using peptide substrate TK-S an... | 37584545 |
| Serine/threonine-protein kinase Chk1 | IC50 | = | 134.65 | nM | 6.87 | Inhibition of CHK1 (unknown origin) using peptide substrate S1 and ATP as substr... | 37584545 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37584545 | 10.1021/acs.jmedchem.3c00245 | Receptor-type tyrosine-protein kinase FLT3 | 1 |
| 37584545 | 10.1021/acs.jmedchem.3c00245 | Serine/threonine-protein kinase Chk1 | 1 |
| 37584545 | 10.1021/acs.jmedchem.3c00245 | MV4-11 | 1 |
Data from ChEMBL 36 via Core Engine