Compound Detail
CHEMBL5431754
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Basic Information
| ChEMBL ID | CHEMBL5431754 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BWKROUZQCPJHCS-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
2
PK Parameters
5
Publications
0
Known Names
Molecular Properties
375.4
MW (Da)
-0.72
ALogP
8
HBA
1
HBD
131.3
PSA (Ų)
0.70
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein cereblon CHEMBL3763008 | IC50 | 7.68 | 7.68 | 21.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.03333 | hr | Homo sapiens |
| T1/2 | 0.03333 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein cereblon | IC50 | = | 21.1 | nM | 7.68 | Displacement of BODIPY-lenalidomide from human N-terminal NanoLuc-fused CRBN exp... | 37974938 |
| Protein cereblon | IC50 | = | 21.0 | nM | 7.68 | Inhibition of CRBN (unknown origin) | 38711345 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37974938 | 10.1021/acsmedchemlett.3c00371 | Protein cereblon | 1 |
| 37974938 | 10.1021/acsmedchemlett.3c00371 | ADMET | 1 |
| 37974938 | 10.1021/acsmedchemlett.3c00371 | Unchecked | 1 |
| 38711345 | 10.1021/acs.jmedchem.3c01825 | ADMET | 1 |
| 38711345 | 10.1021/acs.jmedchem.3c01825 | Protein cereblon | 1 |
Data from ChEMBL 36 via Core Engine