Compound Detail
CHEMBL5433547
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Basic Information
| ChEMBL ID | CHEMBL5433547 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JEEJMGDWLRHOIC-AWEZNQCLSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
352.2
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 20S proteasome CHEMBL3831201 | IC50 | 7.8 | 7.8 | 15.8 | 1 |
| RPMI-8226 CHEMBL614882 | IC50 | 7.24 | 7.24 | 57.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 20S proteasome | IC50 | = | 15.8 | nM | 7.8 | Inhibition of human 20S proteasome chymotrypsin-like activity using Suc-Leu-Leu-... | 36806958 |
| RPMI-8226 | IC50 | = | 57.9 | nM | 7.24 | Cytotoxicity against human RPMI-8226 cells assessed as inhibition of cell prolif... | 36806958 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36806958 | 10.1016/j.ejmech.2023.115187 | 20S proteasome | 1 |
| 36806958 | 10.1016/j.ejmech.2023.115187 | RPMI-8226 | 1 |
Data from ChEMBL 36 via Core Engine