Compound Detail
CHEMBL5440418
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Basic Information
| ChEMBL ID | CHEMBL5440418 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QZFRGVDHHNMEHX-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
308.4
MW (Da)
4.15
ALogP
2
HBA
3
HBD
69.8
PSA (Ų)
0.62
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cyclin-dependent kinase 8 CHEMBL5719 | IC50 | 7.01 | 7.01 | 98.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 8 | IC50 | = | 98.4 | nM | 7.01 | Inhibition of CDK8 (unknown origin) in presence of ATP by ADP-Glo assay | 36889252 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36889252 | 10.1016/j.ejmech.2023.115214 | Cyclin-dependent kinase 8 | 2 |
Data from ChEMBL 36 via Core Engine