Compound Detail
CHEMBL5440473
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Basic Information
| ChEMBL ID | CHEMBL5440473 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VMGHYPWNFXAGJP-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
434.3
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Poly [ADP-ribose] polymerase 2 CHEMBL5366 | IC50 | 6.92 | 6.92 | 120.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Poly [ADP-ribose] polymerase 2 | IC50 | = | 120.0 | nM | 6.92 | Inhibition of N-terminal GST-tagged human PARP2 (2 to 583 residues) expressed in... | 37752013 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37752013 | 10.1021/acs.jmedchem.3c01194 | Poly [ADP-ribose] polymerase 1 | 1 |
| 37752013 | 10.1021/acs.jmedchem.3c01194 | Poly [ADP-ribose] polymerase 2 | 1 |
Data from ChEMBL 36 via Core Engine