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Compound Detail

CHEMBL5440979

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Cc1cc(CN2C(=O)CN(c3ccc(Br)cc3)C2=O)cc(C)c1OC(C)(C)C(=O)O

Basic Information

ChEMBL ID CHEMBL5440979
Phase Preclinical
Structure Type MOL
InChI Key CYJVQDSKBHERNA-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

475.3
MW (Da)
4.28
ALogP
4
HBA
1
HBD
87.2
PSA (Ų)
0.63
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H23BrN2O5
MW 475.34
Aromatic Rings 2
Heavy Atoms 30
NP-Likeness -0.82

Activity Summary

EC50 3 meas. best 8.72

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Peroxisome proliferator-activated receptor delta
CHEMBL3979
EC50 8.72 8.72 1.9 1
Peroxisome proliferator-activated receptor alpha
CHEMBL239
EC50 8.41 8.41 3.9 1
Peroxisome proliferator-activated receptor gamma
CHEMBL235
EC50 5.92 5.92 1204.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
37243609 10.1021/acs.jmedchem.2c02123 Peroxisome proliferator-activated receptor alpha 2
37243609 10.1021/acs.jmedchem.2c02123 Peroxisome proliferator-activated receptor delta 2
37243609 10.1021/acs.jmedchem.2c02123 Peroxisome proliferator-activated receptor gamma 2

Data from ChEMBL 36 via Core Engine