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Compound Detail

CHEMBL549386

FOTEMUSTINE
🧪 Phase III
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🧪 Phase III
CCOP(=O)(OCC)C(C)NC(=O)N(CCCl)N=O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL549386
Name FOTEMUSTINE
Phase Phase III
Structure Type MOL
InChI Key YAKWPXVTIGTRJH-UHFFFAOYSA-N

Known Names

Fotemustina Fotemustine Muphoran Mustophorane S-10036 S10036
0
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
6
Known Names
5
Indications
1
Mechanisms

Molecular Properties

315.7
MW (Da)
2.53
ALogP
6
HBA
1
HBD
97.3
PSA (Ų)
0.31
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Racemic

Flags

Natural Product
USAN Stem -mustine

Extended Properties

Molecular Formula C9H19ClN3O5P
MW 315.69
Aromatic Rings 0
Heavy Atoms 19
NP-Likeness -0.22

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
DNA cross-linking agent CROSS-LINKING AGENT DNA ✓ ✓

Indications

Melanoma Melanoma Neoplasms Uveal Melanoma Glioblastoma

ATC Classification

L01AD05
fotemustine
Level 1: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Level 2: ANTINEOPLASTIC AGENTS

Activity Summary

IC50 4 meas.

Literature References

PubMed DOI Target Context # Activities
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
18513976 10.1016/j.bmc.2008.05.022 NON-PROTEIN TARGET 2
18513976 10.1016/j.bmc.2008.05.022 A-375 1
19278757 10.1016/j.ejmech.2009.02.007 A-375 1

Data from ChEMBL 36 via Core Engine