Compound Detail
CHEMBL550755
FORODESINE HYDROCHLORIDE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL550755 |
| Name | FORODESINE HYDROCHLORIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | WEIAMZKHBCLFOG-QPAIBFMUSA-N |
| Parent Compound | CHEMBL218291 |
| Active Moiety | CHEMBL218291 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
7
Publications
3
Known Names
5
Indications
1
Mechanisms
Molecular Properties
266.3
MW (Da)
-2.02
ALogP
6
HBA
6
HBD
134.3
PSA (Ų)
0.37
QED
1
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2017 |
| Availability | Unknown |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Purine nucleoside phosphorylase inhibitor | INHIBITOR | Purine nucleoside phosphorylase | ✓ | ✓ |
Indications
Leukemia, Lymphocytic, Chronic, B-Cell Leukemia, Lymphoid Lymphoma Lymphoma, T-Cell, Peripheral Neoplasms
Activity Summary
IC50 1 meas. best 9.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Purine nucleoside phosphorylase CHEMBL4338 | IC50 | 9.32 | 9.32 | 0.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Purine nucleoside phosphorylase | IC50 | = | 0.48 | nM | 9.32 | Inhibition of PNP (unknown origin) | 37801827 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 19386496 | 10.1016/j.bmcl.2009.04.018 | Purine nucleoside phosphorylase | 1 |
| 19386498 | 10.1016/j.bmcl.2009.04.017 | Purine nucleoside phosphorylase | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 37801827 | 10.1016/j.ejmech.2023.115835 | Purine nucleoside phosphorylase | 1 |
| 37801827 | 10.1016/j.ejmech.2023.115835 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine