Compound Detail
CHEMBL5532263
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Basic Information
| ChEMBL ID | CHEMBL5532263 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VKVAJBRQGBRHIK-XSFVSMFZSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names
Molecular Properties
275.3
MW (Da)
1.99
ALogP
6
HBA
0
HBD
95.0
PSA (Ų)
0.67
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 8 CHEMBL2157854 | IC50 | 6.55 | 6.55 | 280.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 8 | IC50 | = | 280.0 | nM | 6.55 | Inhibition of human His tagged full-length USP8 expressed in baculovirus infecte... | 38452725 |
| Ubiquitin carboxyl-terminal hydrolase 8 | IC50 | = | 280.0 | nM | 6.55 | Affinity Biochemical interaction: (enzymatic assay (cleavage of fluorogenic Ub-A... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL5724796 | Casein kinase I isoform delta | 2 |
| - | 10.6019/CHEMBL5724796 | Cyclin-dependent kinase 2 | 2 |
| - | 10.6019/CHEMBL5724796 | Glycogen synthase kinase-3 beta | 2 |
| - | 10.6019/CHEMBL5724796 | Mitogen-activated protein kinase 1 | 2 |
| - | 10.6019/CHEMBL5724796 | Aurora kinase A | 2 |
| - | 10.6019/CHEMBL5724796 | Tyrosine-protein kinase ABL1 | 2 |
| - | 10.6019/CHEMBL5724796 | Fibroblast growth factor receptor 2 | 2 |
| - | 10.6019/CHEMBL5724796 | Peregrin | 2 |
| - | 10.6019/CHEMBL5724796 | Transcription intermediary factor 1-alpha | 2 |
| - | 10.6019/CHEMBL5724796 | Bromodomain-containing protein 4 | 2 |
| 38452725 | 10.1016/j.ejmech.2024.116275 | Ubiquitin carboxyl-terminal hydrolase 8 | 1 |
| - | 10.6019/CHEMBL5723035 | Ubiquitin carboxyl-terminal hydrolase 8 | 1 |
Data from ChEMBL 36 via Core Engine