Compound Detail
CHEMBL5532607
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Basic Information
| ChEMBL ID | CHEMBL5532607 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SDXLNXQIWYIZLN-SNVBAGLBSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
350.4
MW (Da)
1.15
ALogP
8
HBA
4
HBD
127.7
PSA (Ų)
0.65
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase Chk1 CHEMBL4630 | IC50 | 7.38 | 7.38 | 41.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase Chk1 | IC50 | = | 41.5 | nM | 7.38 | Inhibition of CHK1 (unknown origin) preincubated with compound for 10 mins follo... | 38547734 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38547734 | 10.1016/j.ejmech.2024.116351 | Serine/threonine-protein kinase Chk1 | 1 |
| 38547734 | 10.1016/j.ejmech.2024.116351 | MV4-11 | 1 |
| 38547734 | 10.1016/j.ejmech.2024.116351 | HT-29 | 1 |
Data from ChEMBL 36 via Core Engine