Compound Detail
CHEMBL5542781
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Basic Information
| ChEMBL ID | CHEMBL5542781 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LEOHZUDNCHSZFZ-GOTSBHOMSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
349.5
MW (Da)
4.32
ALogP
3
HBA
0
HBD
19.4
PSA (Ų)
0.77
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 6 CHEMBL1628465 | IC50 | 6.72 | 6.72 | 190.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 6 | IC50 | = | 190.0 | nM | 6.72 | Inhibition of human TRPV6 (1 to 725 residues) by FLIPR analysis | 38588625 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38588625 | 10.1016/j.ejmech.2024.116379 | Transient receptor potential cation channel subfamily V member 6 | 1 |
Data from ChEMBL 36 via Core Engine