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Compound Detail

CHEMBL554597

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Cl.O=C(O)CCCCCn1ccnc1

Basic Information

ChEMBL ID CHEMBL554597
Phase Preclinical
Structure Type MOL
InChI Key NRMPUDJDEIKDBX-UHFFFAOYSA-N
Parent Compound CHEMBL1195449
Active Moiety CHEMBL1195449
0
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

182.2
MW (Da)
1.53
ALogP
3
HBA
1
HBD
55.1
PSA (Ų)
0.68
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C9H15ClN2O2
MW 218.68
Aromatic Rings 1
Heavy Atoms 13
NP-Likeness -0.86

Activity Summary

IC50 4 meas.

Literature References

PubMed DOI Target Context # Activities
7199089 10.1021/jm00142a006 Thromboxane-A synthase 1
21353350 10.1016/j.ejmech.2011.01.042 Sodium- and chloride-dependent GABA transporter 1 1
21353350 10.1016/j.ejmech.2011.01.042 GABA transporter 3 1
21353350 10.1016/j.ejmech.2011.01.042 GABA transporter 4 1
21353350 10.1016/j.ejmech.2011.01.042 Unchecked 1

Data from ChEMBL 36 via Core Engine