Compound Detail
CHEMBL5555989
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C[Si](C)(C)N1C(=O)C(=P(c2ccccc2)(c2ccccc2)c2ccccc2)P1(c1ccccc1)(c1ccccc1)c1ccccc1
Basic Information
| ChEMBL ID | CHEMBL5555989 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PJVSGLLRFCLHDM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
651.8
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 72 kDa type IV collagenase CHEMBL333 | IC50 | 7.16 | 7.16 | 70.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 72 kDa type IV collagenase | IC50 | = | 70.0 | nM | 7.16 | Inhibition of recombinant MMP-2 (unknown origin) | 38278079 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38278079 | 10.1016/j.ejmech.2024.116152 | 72 kDa type IV collagenase | 1 |
Data from ChEMBL 36 via Core Engine