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Compound Detail

CHEMBL5557387

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C#CCN1c2nc(Nc3cc(F)c(O)c(F)c3)ncc2N(CC#N)C(=O)[C@@H]1C
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL5557387
Phase Preclinical
Structure Type MOL
InChI Key FZCVUEDVVBMAAE-JTQLQIEISA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

384.4
MW (Da)
1.90
ALogP
7
HBA
2
HBD
105.4
PSA (Ų)
0.47
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H14F2N6O2
MW 384.35
Aromatic Rings 2
Heavy Atoms 28
NP-Likeness -1.25

Activity Summary

Ki 1 meas. best 7.58

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Serine/threonine-protein kinase VRK1
CHEMBL1293199
 Ki 7.58 7.58 26.1 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Serine/threonine-protein kinase VRK1 Ki = 26.1 nM 7.58 Inhibition of human VRK1 (3 to 364 residues) expressed in Escherichia coli BL21 ... 38780468

Literature References

PubMed DOI Target Context # Activities
38780468 10.1021/acs.jmedchem.3c02250 Serine/threonine-protein kinase VRK1 1

Data from ChEMBL 36 via Core Engine