Compound Detail
CHEMBL5559649
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Basic Information
| ChEMBL ID | CHEMBL5559649 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IDGGGSXKPHJBAR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
313.1
MW (Da)
2.29
ALogP
4
HBA
1
HBD
67.8
PSA (Ų)
0.81
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 5.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein cereblon CHEMBL3763008 | Ki | 5.42 | 5.42 | 3800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein cereblon | Ki | = | 3800.0 | nM | 5.42 | Binding affinity to human CRBN TBD assessed as inhibition constant using BODIPY-... | 38552426 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38552426 | 10.1016/j.ejmech.2024.116328 | Protein cereblon | 1 |
| 38552426 | 10.1016/j.ejmech.2024.116328 | No relevant target | 1 |
| 38552426 | 10.1016/j.ejmech.2024.116328 | MM1.S | 1 |
| 38552426 | 10.1016/j.ejmech.2024.116328 | KMS-12-PE | 1 |
| 38552426 | 10.1016/j.ejmech.2024.116328 | MOLP-8 | 1 |
| 38552426 | 10.1016/j.ejmech.2024.116328 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine