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Compound Detail

CHEMBL5571780

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CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](N)[C@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H](CSSC[C@H](C(=O)N[C@H](C(N)=O)C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC1=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N2

Basic Information

ChEMBL ID CHEMBL5571780
Phase Preclinical
Structure Type MOL
InChI Key XCCFHIMCLZGLNA-SAJKMHEWSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

3452.0
MW (Da)

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C139H228N56O40S4
MW 3451.97

Activity Summary

IC50 3 meas. best 8.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Voltage-dependent N-type calcium channel subunit alpha-1B
CHEMBL4478
IC50 8.52 8.52 3.0 1
Nicotinic acetylcholine receptor alpha9/alpha10
CHEMBL3038462
IC50 7.64 7.64 22.7 1
Neuronal acetylcholine receptor; alpha9/alpha10
CHEMBL2109238
IC50 6.94 6.94 116.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
38217860 10.1021/acs.jmedchem.3c00979 Nicotinic acetylcholine receptor alpha9/alpha10 1
38217860 10.1021/acs.jmedchem.3c00979 Neuronal acetylcholine receptor; alpha9/alpha10 1
38217860 10.1021/acs.jmedchem.3c00979 Voltage-dependent N-type calcium channel subunit alpha-1B 1

Data from ChEMBL 36 via Core Engine