Compound Detail
CHEMBL5591253
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](NC(=O)c2cnc(N3CCN(CCCOc4cc5ncnc(Nc6n[nH]c(C)c6C)c5cc4S(=O)(=O)C(C)(C)C)CC3)cn2)C[C@@H]1C(=O)Nc1c(F)cccc1F)C(C)(C)C
Basic Information
| ChEMBL ID | CHEMBL5591253 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CHNBEZLJAQUZEX-BPYLYCJUSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1045.2
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cyclin-dependent kinase 12 CHEMBL3559692 | IC50 | 8.0 | 8.0 | 10.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 12 | IC50 | = | 10.0 | nM | 8.0 | Inhibition of CDK12 (unknown origin) | 39149114 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 39149114 | 10.1039/d4md00142g | Cyclin-dependent kinase 12 | 1 |
Data from ChEMBL 36 via Core Engine