Compound Detail
CHEMBL5594876
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CNC(=O)c1ccc(COc2cccc(C3CCN(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)CC3)n2)c(F)c1
Basic Information
| ChEMBL ID | CHEMBL5594876 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RCSBCMNEHBFENF-DEOSSOPVSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
587.6
MW (Da)
4.38
ALogP
8
HBA
2
HBD
118.8
PSA (Ų)
0.28
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucagon-like peptide 1 receptor CHEMBL1784 | EC50 | 6.75 | 6.75 | 179.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucagon-like peptide 1 receptor | EC50 | = | 179.2 | nM | 6.75 | Agonist activity at human GLP-1R expressed in HEK293 cells assessed as accumulat... | 39140772 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 39140772 | 10.1021/acs.jmedchem.4c01177 | Glucagon-like peptide 1 receptor | 1 |
Data from ChEMBL 36 via Core Engine