Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL5596148

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CCCSc1nc2c(c(=O)[nH]1)[C@@H](c1ccc(OC)cc1[N+](=O)[O-])CC(=O)N2

Basic Information

ChEMBL ID CHEMBL5596148
Phase Preclinical
Structure Type MOL
InChI Key PDMTWPGSWBFGFN-LLVKDONJSA-N
0
Targets
0
Activities
0
Assay Types
14
PK Parameters
6
Publications
0
Known Names

Molecular Properties

390.4
MW (Da)
2.66
ALogP
7
HBA
2
HBD
127.2
PSA (Ų)
0.34
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H18N4O5S
MW 390.42
Aromatic Rings 2
Heavy Atoms 27
NP-Likeness -1.35

Pharmacokinetic Data

Parameter Value Units Species
AUC 130551.0 ng.hr.mL-1 Mus musculus
AUC 594611.0 ng.hr.mL-1 Mus musculus
AUC 174781.0 ng.hr.mL-1 Mus musculus
AUC 669417.0 ng.hr.mL-1 Mus musculus
CL 0.5 mL.min-1.kg-1 Mus musculus
Cmax 54.01 ug.mL-1 Mus musculus
F 63.8 % Mus musculus
MRT 16.4 hr Mus musculus
MRT 10.1 hr Mus musculus
T1/2 5.719 hr Mus musculus
T1/2 3.571 hr Homo sapiens
T1/2 13.1 hr Mus musculus
T1/2 7.95 hr Mus musculus
Tmax 0.417 hr Mus musculus

Literature References

PubMed DOI Target Context # Activities
39166949 10.1021/acs.jmedchem.4c00441 ADMET 26
39166949 10.1021/acs.jmedchem.4c00441 Mycobacterium tuberculosis 6
39166949 10.1021/acs.jmedchem.4c00441 Mycobacterium marinum 6
39166949 10.1021/acs.jmedchem.4c00441 HK-2 1
39166949 10.1021/acs.jmedchem.4c00441 Voltage-gated inwardly rectifying potassium channel KCNH2 1
39166949 10.1021/acs.jmedchem.4c00441 Unchecked 1

Data from ChEMBL 36 via Core Engine