Compound Detail
CHEMBL5618477
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O=C1CCC(N2C(=O)c3ccc([C@H]4C[C@@]4(C(=O)OCC(Cl)(Cl)Cl)c4ccc(Br)cc4)cc3C2=O)C(=O)N1
Basic Information
| ChEMBL ID | CHEMBL5618477 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UNLJYDQMMAMQCI-UOZFTJLZSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
628.7
MW (Da)
4.19
ALogP
6
HBA
1
HBD
109.8
PSA (Ų)
0.30
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.39
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sal-like protein 4 CHEMBL6067463 | EC50 | 6.39 | 6.39 | 410.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sal-like protein 4 | EC50 | = | 410.0 | nM | 6.39 | Induction of C-terminal HiBiT tag knocked in SALL4 degradation in human NCCIT ce... | 39291008 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 39291008 | 10.1021/acsmedchemlett.4c00297 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A | 2 |
| 39291008 | 10.1021/acsmedchemlett.4c00297 | Zinc finger protein Aiolos | 1 |
| 39291008 | 10.1021/acsmedchemlett.4c00297 | Casein kinase I isoform alpha | 1 |
| 39291008 | 10.1021/acsmedchemlett.4c00297 | Sal-like protein 4 | 1 |
Data from ChEMBL 36 via Core Engine