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Compound Detail

CHEMBL5619765

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Cc1cc(NCc2ccccc2)n2nc(C)c(-c3ccccc3)c2n1

Basic Information

ChEMBL ID CHEMBL5619765
Phase Preclinical
Structure Type MOL
InChI Key KGWCTROONONUPE-UHFFFAOYSA-N
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

328.4
MW (Da)
4.63
ALogP
4
HBA
1
HBD
42.2
PSA (Ų)
0.59
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H20N4
MW 328.42
Aromatic Rings 4
Heavy Atoms 25
NP-Likeness -1.54

Activity Summary

EC50 2 meas. best 5.72
IC50 1 meas. best 5.82

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Phosphatidylinositol 4-kinase beta
CHEMBL3268
IC50 5.82 5.82 1509.0 1
rhinovirus A21
CHEMBL612371
EC50 5.72 5.72 1900.0 1
rhinovirus B14
CHEMBL613759
EC50 5.7 5.7 2000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
39032404 10.1016/j.ejmech.2024.116690 ADMET 2
39032404 10.1016/j.ejmech.2024.116690 Phosphatidylinositol 4-kinase beta 1
39032404 10.1016/j.ejmech.2024.116690 H1-HeLa 1
39032404 10.1016/j.ejmech.2024.116690 rhinovirus B14 1
39032404 10.1016/j.ejmech.2024.116690 rhinovirus A21 1
39032404 10.1016/j.ejmech.2024.116690 Phosphatidylinositol 4-kinase alpha 1

Data from ChEMBL 36 via Core Engine