Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL5624541

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CC(C)C[C@@H](B(O)O)N(C(=O)c1cnccn1)[C@@H](Cc1ccccc1)C(N)=O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL5624541
Phase Preclinical
Structure Type MOL
InChI Key QEYYWEDSEDCTJL-IRXDYDNUSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

384.2
MW (Da)

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H25BN4O4
MW 384.25

Activity Summary

Ki 1 meas. best 9.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
20S proteasome
CHEMBL3831201
 Ki 9.22 9.22 0.6 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
20S proteasome Ki = 0.6 nM 9.22 Binding affinity to 20s proteosome (unknown origin) assessed as inhibition const... 37210838

Literature References

PubMed DOI Target Context # Activities
37210838 10.1016/j.ejmech.2023.115492 20S proteasome 1

Data from ChEMBL 36 via Core Engine