Compound Detail
CHEMBL562562
SCORZODIHYDROSTILBENE A Enter ChEMBL ID:
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COc1cc(CCc2c(O)ccc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c2C(C)=O)ccc1O
Basic Information
| ChEMBL ID | CHEMBL562562 |
| Name | SCORZODIHYDROSTILBENE A |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YRCZOJOYJCLBDV-DODNOZFWSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
16
Publications
0
Known Names
Molecular Properties
464.5
MW (Da)
0.27
ALogP
10
HBA
6
HBD
166.1
PSA (Ų)
0.30
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL2292 | IC50 | 5.64 | 5.64 | 2300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | IC50 | = | 2300.0 | nM | 5.64 | Inhibition of recombinant human DYRK1A expressed in Sf9 insect cells incubated f... | 36876904 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36876904 | 10.1021/acs.jmedchem.2c02068 | Unchecked | 3 |
| 19271716 | 10.1021/np800782f | Radical scavenging activity | 1 |
| 19271716 | 10.1021/np800782f | L5178Y | 1 |
| 36876904 | 10.1021/acs.jmedchem.2c02068 | Cyclin-dependent kinase 5/CDK5 activator 1 | 1 |
| 36876904 | 10.1021/acs.jmedchem.2c02068 | Casein kinase I isoform epsilon | 1 |
| 36876904 | 10.1021/acs.jmedchem.2c02068 | Dual specificity protein kinase CLK1 | 1 |
| 36876904 | 10.1021/acs.jmedchem.2c02068 | Dual specificity protein kinase CLK2 | 1 |
| 36876904 | 10.1021/acs.jmedchem.2c02068 | Dual specificity protein kinase CLK3 | 1 |
| 36876904 | 10.1021/acs.jmedchem.2c02068 | Dual specificity protein kinase CLK4 | 1 |
| 36876904 | 10.1021/acs.jmedchem.2c02068 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 1 |
| 36876904 | 10.1021/acs.jmedchem.2c02068 | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | 1 |
| 36876904 | 10.1021/acs.jmedchem.2c02068 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | 1 |
| 36876904 | 10.1021/acs.jmedchem.2c02068 | Dual specificity tyrosine-phosphorylation-regulated kinase 3 | 1 |
| 36876904 | 10.1021/acs.jmedchem.2c02068 | Dual specificity tyrosine-phosphorylation-regulated kinase 4 | 1 |
| 36876904 | 10.1021/acs.jmedchem.2c02068 | Glycogen synthase kinase-3 beta | 1 |
| 36876904 | 10.1021/acs.jmedchem.2c02068 | HT-22 | 1 |
Data from ChEMBL 36 via Core Engine