Compound Detail
CHEMBL5631753
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Basic Information
| ChEMBL ID | CHEMBL5631753 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CWVBFSQTTNHODF-KRWDZBQOSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
422.5
MW (Da)
3.30
ALogP
6
HBA
1
HBD
84.4
PSA (Ų)
0.64
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 5.84
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-interacting serine/threonine-protein kinase 1 CHEMBL5464 | Ki | 5.84 | 5.84 | 1445.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-interacting serine/threonine-protein kinase 1 | Ki | = | 1445.44 | nM | 5.84 | Inhibition of human RIPK1 assessed as inhibition constant by ADP-Glo Kinase assa... | 38316369 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38316369 | 10.1016/j.bmcl.2024.129643 | Receptor-interacting serine/threonine-protein kinase 1 | 2 |
| 38316369 | 10.1016/j.bmcl.2024.129643 | Mitogen-activated protein kinase kinase kinase 9 | 1 |
Data from ChEMBL 36 via Core Engine