Compound Detail
CHEMBL5632777
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Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCN(C(=O)CN2CCN(CC3CN(c4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)CC2)CC1
Basic Information
| ChEMBL ID | CHEMBL5632777 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BZECJEIHNUUQGB-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
837.9
MW (Da)
3.19
ALogP
14
HBA
2
HBD
192.4
PSA (Ų)
0.20
QED
2
Ro5 Violations
10
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein cereblon/Tyrosine-protein kinase BTK CHEMBL4523704 | EC50 | 8.14 | 8.09 | 7.3 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein cereblon/Tyrosine-protein kinase BTK | EC50 | = | 7.27 | nM | 8.14 | PROTAC activity at CRBN/BTK in human Ramos cells assessed as induction of BTK de... | 37487306 |
| Protein cereblon/Tyrosine-protein kinase BTK | EC50 | = | 9.06 | nM | 8.04 | PROTAC activity at CRBN/BTK in human MINO cells assessed as induction of BTK deg... | 37487306 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37487306 | 10.1016/j.ejmech.2023.115664 | Protein cereblon/Tyrosine-protein kinase BTK | 7 |
Data from ChEMBL 36 via Core Engine