Compound Detail
CHEMBL5633554
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Basic Information
| ChEMBL ID | CHEMBL5633554 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WNSLCYTWPQLIRB-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
458.9
MW (Da)
5.50
ALogP
7
HBA
2
HBD
85.4
PSA (Ų)
0.40
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.06 | 7.06 | 87.0 | 1 |
| Vascular endothelial growth factor receptor 1 CHEMBL1868 | IC50 | 6.96 | 6.96 | 110.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 87.0 | nM | 7.06 | Inhibition of VEGFR-2 (unknown origin) | 37453330 |
| Vascular endothelial growth factor receptor 1 | IC50 | = | 110.0 | nM | 6.96 | Inhibition of VEGFR-1 (unknown origin) | 37453330 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37453330 | 10.1016/j.ejmech.2023.115626 | Vascular endothelial growth factor receptor 2 | 1 |
| 37453330 | 10.1016/j.ejmech.2023.115626 | Vascular endothelial growth factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine