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Compound Detail

CHEMBL563557

BREVIANAMIDE F
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O=C1N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N2CCC[C@@H]12

Basic Information

ChEMBL ID CHEMBL563557
Name BREVIANAMIDE F
Phase Preclinical
Structure Type MOL
InChI Key RYFZBPVMVYTEKZ-KBPBESRZSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
14
Publications
0
Known Names

Molecular Properties

283.3
MW (Da)
1.20
ALogP
2
HBA
2
HBD
65.2
PSA (Ų)
0.87
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C16H17N3O2
MW 283.33
Aromatic Rings 2
Heavy Atoms 21
NP-Likeness 0.62

Literature References

PubMed DOI Target Context # Activities
19113967 10.1021/np800501m Tryprostatin B synthase ftmPT1 6
22617493 10.1016/j.bmcl.2012.04.119 A2780 2
27865702 10.1016/j.bmcl.2016.11.013 Broad substrate specificity ATP-binding cassette transporter ABCG2 2
39140432 10.1021/acs.jnatprod.4c00334 BV-2 2
22617493 10.1016/j.bmcl.2012.04.119 K562 1
22409377 10.1021/jf300146n Artemia salina 1
- 10.1039/C3MD20353K HeLa 1
26099531 10.1016/j.bmcl.2015.06.010 Staphylococcus aureus 1
26099531 10.1016/j.bmcl.2015.06.010 Bacillus subtilis 1
26099531 10.1016/j.bmcl.2015.06.010 Escherichia coli 1
30685527 10.1016/j.ejmech.2019.01.026 Mycobacterium tuberculosis 1
33153766 10.1016/j.ejmech.2020.112945 Mycobacterium tuberculosis 1
33153766 10.1016/j.ejmech.2020.112945 Staphylococcus aureus 1
33153766 10.1016/j.ejmech.2020.112945 Candida albicans 1

Data from ChEMBL 36 via Core Engine