Compound Detail
CHEMBL5639468
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Basic Information
| ChEMBL ID | CHEMBL5639468 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LLAWYVWENAOOFO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
2
PK Parameters
3
Publications
0
Known Names
Molecular Properties
381.9
MW (Da)
4.28
ALogP
2
HBA
3
HBD
76.8
PSA (Ų)
0.62
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma CHEMBL1908383 | IC50 | 9.1 | 9.1 | 0.8 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 14.9 | mL.min-1.kg-1 | Mus musculus |
| Fu | 0.00012 | - | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma | IC50 | = | 0.8 | nM | 9.1 | Inhibition of N-terminal 6His-tagged full-length recombinant human PIP5K1C expre... | 38746884 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38746884 | 10.1021/acsmedchemlett.4c00090 | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma | 2 |
| 38746884 | 10.1021/acsmedchemlett.4c00090 | ADMET | 2 |
| 38746884 | 10.1021/acsmedchemlett.4c00090 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine