Compound Detail
CHEMBL5646709
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Basic Information
| ChEMBL ID | CHEMBL5646709 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SBVSHHUAWKWVRL-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
361.4
MW (Da)
3.93
ALogP
2
HBA
3
HBD
76.8
PSA (Ų)
0.65
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma CHEMBL1908383 | IC50 | 8.68 | 8.68 | 2.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma | IC50 | = | 2.1 | nM | 8.68 | Inhibition of N-terminal 6His-tagged full-length recombinant human PIP5K1C expre... | 38746884 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38746884 | 10.1021/acsmedchemlett.4c00090 | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma | 1 |
Data from ChEMBL 36 via Core Engine