Compound Detail
CHEMBL565882
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL565882 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FFFUQLICAJOHFJ-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
7
PK Parameters
2
Publications
0
Known Names
Molecular Properties
304.3
MW (Da)
2.98
ALogP
4
HBA
2
HBD
97.8
PSA (Ų)
0.61
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 9.0
Ki 1 meas. best 9.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Poly [ADP-ribose] polymerase 1 CHEMBL3105 | Ki | 9.12 | 9.12 | 0.8 | 1 |
| Poly [ADP-ribose] polymerase 1 CHEMBL3105 | EC50 | 9.0 | 9.0 | 1.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 164.33 | ng.hr.mL-1 | Mus musculus |
| AUC | 33.47 | ng.hr.mL-1 | Mus musculus |
| CL | 300.0 | mL.min-1.kg-1 | Mus musculus |
| Cmax | 70.0 | nM | Mus musculus |
| F | 6.0 | % | Mus musculus |
| T1/2 | 0.97 | hr | Mus musculus |
| Vd | 26.0 | L.kg-1 | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Poly [ADP-ribose] polymerase 1 | Ki | = | 0.76 | nM | 9.12 | Inhibition of PARP1 by scintillation counting | 19888760 |
| Poly [ADP-ribose] polymerase 1 | EC50 | = | 0.99 | nM | 9.0 | Inhibition of PARP1 in human C41 cells after 30 mins by cell-based assay | 19888760 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19888760 | 10.1021/jm900697r | Mus musculus | 7 |
| 19888760 | 10.1021/jm900697r | Poly [ADP-ribose] polymerase 1 | 2 |
Data from ChEMBL 36 via Core Engine