Compound Detail
CHEMBL568795
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Basic Information
| ChEMBL ID | CHEMBL568795 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AETOKTHGOLBNQY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
285.8
MW (Da)
1.95
ALogP
4
HBA
2
HBD
70.6
PSA (Ų)
0.83
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sulfonylurea receptor 1, Kir6.2 CHEMBL2096972 | EC50 | 7.1 | 7.1 | 80.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sulfonylurea receptor 1, Kir6.2 | EC50 | = | 80.0 | nM | 7.1 | Activation of human recombinant SUR1/Kir6.2 channel expressed in HEK293 cells as... | 19919106 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19919106 | 10.1021/jm9010093 | Unchecked | 4 |
| 19919106 | 10.1021/jm9010093 | Sulfonylurea receptor 1, Kir6.2 | 2 |
| 19919106 | 10.1021/jm9010093 | Aorta | 1 |
Data from ChEMBL 36 via Core Engine