Compound Detail

CHEMBL568927

TYROCIDINE B

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CC(C)C[C@@H]1NC(=O)[C@H](CCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC1=O

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL568927
Name	TYROCIDINE B
Phase	Preclinical
Structure Type	BOTH
InChI Key	PUVWPDQSNYAMEH-UQHIYWQBSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

1309.5

MW (Da)

Drug Information

Molecule Type	Protein
Availability	Unknown
Chirality	Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula	C68H88N14O13
MW	1309.54

Activity Summary

IC50 3 meas. best 5.19

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Micrococcus luteus CHEMBL614421	IC50	5.19	5.19	6500.0	1
Listeria monocytogenes CHEMBL614974	IC50	5.11	5.055	7700.0	2

Pharmacokinetic Data

Parameter	Value	Units	Species
T1/2	0.48	hr	Listeria monocytogenes

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Micrococcus luteus	IC50	=	6500.0	nM	5.19	Antibacterial activity against Micrococcus luteus NCTC 8340 after 16 hrs by brot...	19586775
Listeria monocytogenes	IC50	=	7700.0	nM	5.11	Antibacterial activity against leucocin A-resistant Listeria monocytogenes B73-M...	19586775
Listeria monocytogenes	IC50	=	10000.0	nM	5.0	Antibacterial activity against leucocin A-sensitive Listeria monocytogenes B73 a...	19586775

Literature References

PubMed	DOI	Target Context	# Activities
19586775	10.1016/j.bmc.2009.06.029	Listeria monocytogenes	7
19586775	10.1016/j.bmc.2009.06.029	Micrococcus luteus	2
19586775	10.1016/j.bmc.2009.06.029	Escherichia coli	1

Data from ChEMBL 36 via Core Engine