Compound Detail
CHEMBL569182
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Basic Information
| ChEMBL ID | CHEMBL569182 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FJXHQJTYKKPMGO-ZIAGYGMSSA-N |
1
Targets
1
Activities
1
Assay Types
5
PK Parameters
2
Publications
0
Known Names
Molecular Properties
434.8
MW (Da)
5.71
ALogP
4
HBA
1
HBD
39.1
PSA (Ų)
0.54
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Extracellular calcium-sensing receptor CHEMBL1878 | EC50 | 7.64 | 7.64 | 23.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 36.0 | ng/L | Rattus norvegicus |
| AUC | 0.444 | ng.hr.mL-1 | Rattus norvegicus |
| CL | 21.67 | mL.min-1.kg-1 | Rattus norvegicus |
| F | 24.0 | % | Rattus norvegicus |
| MRT | 11.8 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Extracellular calcium-sensing receptor | EC50 | = | 23.0 | nM | 7.64 | Activity at human CaSR expressed in HEK293 cells assessed as calcium release by ... | 19835382 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19835382 | 10.1021/jm9012278 | Rattus norvegicus | 7 |
| 19835382 | 10.1021/jm9012278 | Extracellular calcium-sensing receptor | 1 |
Data from ChEMBL 36 via Core Engine