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Compound Detail

CHEMBL569693

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N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CC1=CN=CC1)NC(=O)CCCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O

Basic Information

ChEMBL ID CHEMBL569693
Phase Preclinical
Structure Type MOL
InChI Key JYATZOPCEQVXLS-TWHRXLCVSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

789.0
MW (Da)
2.41
ALogP
7
HBA
9
HBD
249.5
PSA (Ų)
0.03
QED
2
Ro5 Violations
22
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C43H52N10O5
MW 788.95
Aromatic Rings 4
Heavy Atoms 58
NP-Likeness 0.07

Activity Summary

EC50 5 meas. best 11.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Melanocyte-stimulating hormone receptor
CHEMBL3795
EC50 11.0 11.0 0.0 1
Melanocortin receptor 5
CHEMBL4489
EC50 9.48 9.48 0.3 1
Melanocortin receptor 4
CHEMBL3719
EC50 9.27 9.27 0.5 1
Melanocyte-stimulating hormone receptor
CHEMBL4077
EC50 8.8 8.8 1.6 1
Melanocortin receptor 3
CHEMBL4774
EC50 7.58 7.58 26.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19635667 10.1016/j.bmcl.2009.07.025 Unchecked 3
19635667 10.1016/j.bmcl.2009.07.025 Melanocyte-stimulating hormone receptor 2
19635667 10.1016/j.bmcl.2009.07.025 Melanocortin receptor 3 1
19635667 10.1016/j.bmcl.2009.07.025 Melanocortin receptor 4 1
19635667 10.1016/j.bmcl.2009.07.025 Melanocortin receptor 5 1

Data from ChEMBL 36 via Core Engine