Compound Detail
CHEMBL5712052
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CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(CCCCc4cn(CCN5C(=O)/C(=C/C=C/C=C6\N(CCC(=O)OCOC(C)=O)c7ccc(C(=O)OCOC(C)=O)cc7C6(C)C)C(=O)N(CC)C5=O)nn4)CC3)nc2)cc2c1cnn2C(C)C
Basic Information
| ChEMBL ID | CHEMBL5712052 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KPLMFJOHLDZNOO-YABVTERDSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1288.5
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase EZH2 CHEMBL2189110 | IC50 | 7.68 | 7.68 | 21.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase EZH2 | IC50 | = | 21.0 | nM | 7.68 | Inhibition of EZH2 methyltransferase activity (unknown origin) in PRC2 complex u... | 23614352 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23614352 | 10.1021/cb400133j | Histone-lysine N-methyltransferase EZH2 | 3 |
Data from ChEMBL 36 via Core Engine