Compound Detail
CHEMBL574060
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL574060 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RIYCICFDXLNQPV-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
285.2
MW (Da)
1.78
ALogP
6
HBA
2
HBD
117.7
PSA (Ų)
0.52
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Casein kinase II subunit alpha CHEMBL3629 | Ki | 6.11 | 6.105 | 780.0 | 2 |
| Casein kinase 2 CHEMBL3832943 | Ki | 6.11 | 6.11 | 780.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Casein kinase II subunit alpha | Ki | = | 780.0 | nM | 6.11 | Inhibitory constant against maize casein kinase 2 | 12419810 |
| Casein kinase 2 | Ki | = | 780.0 | nM | 6.11 | Binding affinity to CK2 (unknown origin) assessed as inhibition constant | 36745746 |
| Casein kinase II subunit alpha | Ki | = | 800.0 | nM | 6.1 | Inhibition of CK2alpha (unknown origin) | 31400711 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12419810 | 10.1074/jbc.m209367200 | Casein kinase II subunit alpha | 1 |
| 31400711 | 10.1016/j.ejmech.2019.111581 | Casein kinase II subunit alpha | 1 |
| 36745746 | 10.1021/acs.jmedchem.2c01523 | Casein kinase 2 | 1 |
Data from ChEMBL 36 via Core Engine