Compound Detail
CHEMBL5741552
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CC(C)NCC(O)CCn1c([C@H](C)Nc2nc(N)nc(N)c2C#N)nc2cccc(Cl)c2c1=O
Basic Information
| ChEMBL ID | CHEMBL5741552 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BVXBGILNPSNTDO-UEWDXFNNSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
486.0
MW (Da)
1.80
ALogP
11
HBA
5
HBD
180.8
PSA (Ų)
0.30
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform CHEMBL3130 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| Phosphatidylinositol 3-kinase regulatory subunit beta CHEMBL4437 | IC50 | 7.77 | 7.77 | 17.0 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267 | IC50 | 5.79 | 5.79 | 1620.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | IC50 | = | 1.0 | nM | 9.0 | a time-resolved fluorescence resonance energy transfer (TR-FRET) assay: Class I ... | - |
| Phosphatidylinositol 3-kinase regulatory subunit beta | IC50 | = | 17.0 | nM | 7.77 | a time-resolved fluorescence resonance energy transfer (TR-FRET) assay: Class I ... | - |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | IC50 | = | 1620.0 | nM | 5.79 | a time-resolved fluorescence resonance energy transfer (TR-FRET) assay: Class I ... | - |
Data from ChEMBL 36 via Core Engine