Compound Detail
CHEMBL5744208
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Cc1c2c(nn1C)C(C)OCCCCn1c(C(=O)O)c(CCCOc3cccc4ccccc34)c3cccc-2c31
Basic Information
| ChEMBL ID | CHEMBL5744208 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GSHPRFUNVKYWPO-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
537.7
MW (Da)
7.08
ALogP
6
HBA
1
HBD
78.5
PSA (Ų)
0.23
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 8.92 | 8.4133 | 1.2 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 1.2 | nM | 8.92 | Protein-Protein Interaction Assay: MCL-1/Noxa BH3 Peptide (MCL-1 Assay): The dos... | - |
| Unchecked | IC50 | = | 2.2 | nM | 8.66 | Protein-Protein Interaction Assay: MCL-1/Noxa BH3 Peptide (MCL-1 Assay): The dos... | - |
| Unchecked | IC50 | = | 22.0 | nM | 7.66 | Protein-Protein Interaction Assay: MCL-1/Noxa BH3 Peptide (MCL-1 Assay): The dos... | - |
Data from ChEMBL 36 via Core Engine