Compound Detail
CHEMBL5750925
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C=C/C=C1/CN(C(=O)CCCC2(C)CCC(Cc3ccc(C4CCC(C)CC4)cc3)CC2)CC1=C
Basic Information
| ChEMBL ID | CHEMBL5750925 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WCHKLYGEPGACDR-WXWNMJPKSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
473.8
MW (Da)
8.40
ALogP
1
HBA
0
HBD
20.3
PSA (Ų)
0.37
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nicotinamide phosphoribosyltransferase CHEMBL1744525 | IC50 | 8.2 | 8.2 | 6.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nicotinamide phosphoribosyltransferase | IC50 | = | 6.37 | nM | 8.2 | Biochemical Inhibition Assay: NAMPT Protein Purification. Recombinant His-tagged... | - |
Data from ChEMBL 36 via Core Engine