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Compound Detail

CHEMBL5757642

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O=C(O)CCCOc1ccc(F)cc1-c1cc(-c2ccccc2Cl)n(-c2ccccc2)n1

Basic Information

ChEMBL ID CHEMBL5757642
Phase Preclinical
Structure Type MOL
InChI Key KKGSJSNHHZYDNB-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

450.9
MW (Da)
6.24
ALogP
4
HBA
1
HBD
64.3
PSA (Ų)
0.32
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H20ClFN2O3
MW 450.90
Aromatic Rings 4
Heavy Atoms 32
NP-Likeness -1.26

Activity Summary

Kd 2 meas. best 6.01

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Fatty acid-binding protein, heart
CHEMBL3344
Kd 6.01 6.01 968.0 1
Unchecked
CHEMBL612545
Kd 5.95 5.95 1113.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine