Compound Detail
CHEMBL5766201
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5766201 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LPVOWHYKCXVVQA-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
443.5
MW (Da)
3.13
ALogP
8
HBA
1
HBD
116.9
PSA (Ų)
0.64
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAF proto-oncogene serine/threonine-protein kinase CHEMBL1906 | IC50 | 8.85 | 8.795 | 1.4 | 2 |
| Unchecked CHEMBL612545 | IC50 | 8.53 | 8.53 | 3.0 | 1 |
| Serine/threonine-protein kinase B-raf CHEMBL5145 | IC50 | 8.32 | 8.32 | 4.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAF proto-oncogene serine/threonine-protein kinase | IC50 | = | 1.42 | nM | 8.85 | In Vitro Raf Activity: Raf and biotinylated Mek, kinase dead, were combined at 2... | - |
| RAF proto-oncogene serine/threonine-protein kinase | IC50 | = | 1.8 | nM | 8.74 | In Vitro Raf Activity: Raf and biotinylated Mek, kinase dead, were combined at 2... | - |
| Unchecked | IC50 | = | 2.95 | nM | 8.53 | In Vitro Raf Activity: Raf and biotinylated Mek, kinase dead, were combined at 2... | - |
| Serine/threonine-protein kinase B-raf | IC50 | = | 4.8 | nM | 8.32 | In Vitro Raf Activity: Raf and biotinylated Mek, kinase dead, were combined at 2... | - |
Data from ChEMBL 36 via Core Engine