Compound Detail
CHEMBL5768430
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Basic Information
| ChEMBL ID | CHEMBL5768430 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KDBCNDYXFRQBOP-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
499.0
MW (Da)
4.59
ALogP
6
HBA
1
HBD
65.5
PSA (Ų)
0.48
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium channel protein type 8 subunit alpha CHEMBL5202 | IC50 | 6.82 | 6.6525 | 152.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium channel protein type 8 subunit alpha | IC50 | = | 152.0 | nM | 6.82 | Electrophysiological Assay (In Vitro Assay): Patch voltage clamp electrophysiolo... | - |
| Sodium channel protein type 8 subunit alpha | IC50 | = | 152.0 | nM | 6.82 | Electrophysiological Assay: The following patch voltage clamp electrophysiology ... | - |
| Sodium channel protein type 8 subunit alpha | IC50 | = | 152.0 | nM | 6.82 | Electrophysiological Assay (In Vitro Assay): Sodium currents were measured using... | - |
| Sodium channel protein type 8 subunit alpha | IC50 | = | 703.0 | nM | 6.15 | Sodium Influx Assay (In Vitro Assay): This sodium influx assay employs the use o... | - |
Data from ChEMBL 36 via Core Engine