Compound Detail
CHEMBL5769291
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Basic Information
| ChEMBL ID | CHEMBL5769291 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HEATXCIQCUAIBN-UHFFFAOYSA-N |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
291.4
MW (Da)
3.74
ALogP
4
HBA
2
HBD
72.5
PSA (Ų)
0.59
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 7.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase receptor Ret CHEMBL2041 | IC50 | 7.51 | 6.455 | 30.7 | 4 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.07 | 5.07 | 8530.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase receptor Ret | IC50 | = | 30.7 | nM | 7.51 | Time-Resolved Fluorescence Transfer (FRET) Assay: RET and KDR: Kinase activity w... | - |
| Proto-oncogene tyrosine-protein kinase receptor Ret | IC50 | = | 30.7 | nM | 7.51 | RET and KDR Enzyme Assay: Kinase activity was detected using CisBio HTRF kinEASE... | - |
| Proto-oncogene tyrosine-protein kinase receptor Ret | IC50 | = | 3970.0 | nM | 5.4 | Time-Resolved Fluorescence Transfer (FRET) Assay: RET and KDR: Kinase activity w... | - |
| Proto-oncogene tyrosine-protein kinase receptor Ret | IC50 | = | 3970.0 | nM | 5.4 | RET and KDR Enzyme Assay: Kinase activity was detected using CisBio HTRF kinEASE... | - |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 8530.0 | nM | 5.07 | Time-Resolved Fluorescence Transfer (FRET) Assay: RET and KDR: Kinase activity w... | - |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 8530.0 | nM | 5.07 | RET and KDR Enzyme Assay: Kinase activity was detected using CisBio HTRF kinEASE... | - |
Data from ChEMBL 36 via Core Engine