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Compound Detail

CHEMBL5772856

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CC(=O)NCC#Cc1cc2cc(NC(=O)[C@@H]3CCCN3C(=O)[C@H](NC(=O)OC(C)(C)C)c3ccccc3)ccc2[nH]1

Basic Information

ChEMBL ID CHEMBL5772856
Phase Preclinical
Structure Type MOL
InChI Key VLTILDQPMYQBPI-RRPNLBNLSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

557.6
MW (Da)
3.85
ALogP
5
HBA
4
HBD
132.6
PSA (Ų)
0.34
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H35N5O5
MW 557.65
Aromatic Rings 3
Heavy Atoms 41
NP-Likeness -1.09

Activity Summary

EC50 1 meas. best 6.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 6.5 6.5 317.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked EC50 = 317.0 nM 6.5 Measuring Compound Inhibitory Potency: Measurement of inhibition by compounds wa... -

Data from ChEMBL 36 via Core Engine