Compound Detail
CHEMBL577800
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Basic Information
| ChEMBL ID | CHEMBL577800 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MZXOJLUENNUYRY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
438.0
MW (Da)
5.10
ALogP
5
HBA
1
HBD
64.0
PSA (Ų)
0.51
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.71
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 4.71 | 4.71 | 19400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 19400.0 | nM | 4.71 | Inhibition of gamma-secretase-mediated cleavage of human APP expressed in CHO ce... | 19443228 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19443228 | 10.1016/j.bmc.2009.04.052 | Unchecked | 4 |
Data from ChEMBL 36 via Core Engine